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Triapine shows broad spectrum antitumor activity by inhibiting DNA synthesis in a series of cancer cell lines. In vitro, Triapine blocks ischemic neurotoxicity and hypoxic toxicity with EC50 of 0.35 μM and 0.75 μM, respectively. Triapine also shows its neuroprotective activity by suppressing cell death induced by neurotoxic agents, including ...

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Triapine|Ribonucleotide reductase inhibitor|CAS# 236392-56-6

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Triapine is a potent inhibitor of ribonucleotide reductase activity with IC50 value of 1.6 μM for various of tumor cell lines [1]. Triapine has been reported to inhibit ribonucleotide reductase activity. Triapine has shown its antineoplastic act

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Triapine | CAS 200933-27-3 | SCBT - Santa Cruz Biotechnology

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Triapine(236392-56-6) Reference standards for Pharmacological research. Triapine is a potent inhibitor of ribonucleotide reductase activity with IC50 value of 1.6 μM for various of tumor cell lines [1]

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Triapine | Chemicals eBiochemicals

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eBiochemicals provides information on the Triapine(3-AP;PAN-811;OCX191;NSC663249; (E)-2-((3-aminopyridin-2-yl)methylene)hydrazinecarbothioamide): structure, NMR,MS,IR,spectral data, msds, molecular formula, cas, physical and chemical properties, and suppliers. ... molecular formula, cas, physical and chemical properties, and suppliers. Welcome ...

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Triapine | 3-AP | CAS#143621-35-6 | 236392-56-6 | MedKoo ...

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Triapine, also known as 3-AP and OCX-191, is a synthetic heterocyclic carboxaldehyde thiosemicarbazone with potential antineoplastic activity. Triapine inhibits the enzyme ribonucleotide reductase, resulting in the inhibition of the conversion of ribonucleoside diphosphates to deoxyribonucleotides necessary for DNA synthesis. This agent has been shown to inhibit tumor …

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Triapine - InvivoChem

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Triapine Related products InvivoChem Cat #: V1441; CAS #: 143621-35-6 Description: Triapine (also known as 3-AP) is a potent ribonucleotide reductase inhibitor and a potent radiosensitizer with broad spectrum antitumor activity by inhibiting DNA synthesis. It inhibits the M2 subunit of ribonucleotide reductase. In addition, Triapine has been revealed to inhibit the growth of the murine M109 ...

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Triapine is a potent ribonucleotide reductase inhibitor with broad spectrum antitumor activity by inhibiting DNA synthesis.

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CAS # 143621-35-6, Triapine, 3-AP, 3-Aminopyridine-2 ...

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chemBlink provides information about CAS # 143621-35-6, Triapine, 3-AP, 3-Aminopyridine-2-carboxaldehyde thiosemicarbazone, NSC 663249, OCX 0191, …

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Pracinostat • Focus Bioscience

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Pracinostat (25 or 50 mg/kg per day for 21 days) induces significant inhibition of tumor growth (TGI), by 59 and 116%, respectively, in mice bearing MV4-11 xenografts. Pracinostat (75 mg/kg, q.o.d) in combination with pacritinib is efficacious and synergistic in vivo in two different models of human AML.

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3-AP is a ribonucleotide reductase inhibitor and iron chelator with antitumor activity. Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is an excellent target for chemotherapy. The increased activity of ribonucleot

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This disclosure relates, at least in part, to a method of treatment. In one embodiment, the method of treatment comprises administering to a subject in need of such treatment a first therapeutic agent including compound (1): or a pharmaceutically acceptable salt thereof in combination with a second therapeutic agent, wherein the first therapeutic agent and the second therapeutic agent are ...

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US9265765B2 - 7-benzyl-10-(2-methylbenzyl)-2,6,7,8,9,10 ...

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This disclosure relates, at least in part, to a method of treatment. In one embodiment, the method of treatment comprises administering to a subject in need of such treatment a first therapeutic agent including compound (1): or a pharmaceutically acceptable salt thereof in combination with a second therapeutic agent, wherein the first therapeutic agent and the second therapeutic agent are ...

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A search for structural analogues of the confirmed MDR-selective compounds, based on Tanimoto coefficients (with a threshold distance of 0.6), led to the identification of 15 additional MDR-selective compounds and also set the stage for preliminary structure–activity realtionship (SAR) studies.

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Nardosinone | CAS:23720-80-1 For Research Use | High ...

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Nardosinone enhances nerve growth factor-induced neurite outgrowth in a mitogen-activated protein kinase- and protein kinase C-dependent manner in PC12D cells.[Pubmed: 14501162] The mechanism to enhance nerve growth factor (NGF, 2 ng/ml)-induced neurite outgrowth from PC12D cells by Nardosinone isolated from Nardostachys chinensis was examined.

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Modern Pharmaceuticals - January 2011 by Infomedia18 - Issuu

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The Hsp70 family members play an essential role in cellular protein metabolism by acting as polypeptide-binding and release factors that interact with nonnative regions of protein

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9/18/2014 · This disclosure relates, at least in part, to a method of treatment. In one embodiment, the method of treatment comprises administering to a subject in need of such treatment a first therapeutic agent including compound (1):

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Compounds in which a methyl group is attached to the cyano moiety. | Explore the latest articles, projects, and questions and answers in Acetonitriles, and find Acetonitriles experts.

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10/15/2018 · Innovative Research's Single Donor Human Serum was recently used in the following study: MATERIALS AND METHODS Patients SP accession No, N accession No, D Glycoprotein - Genome... Samples were stored at 70C. Purchased sera from 60 healthy donors (Innovative Research Inc., Novi, MI, USA) were included as controls.This study was approved by the Institutional Review Board of …

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Gallium-containing anticancer compounds | Future Medicinal ...

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7/16/2012 · There is an ever pressing need to develop new drugs for the treatment of cancer. Gallium nitrate, a group IIIa metal salt, inhibits the proliferation of tumor cells in vitro and in vivo and has shown activity against non-Hodgkin’s lymphoma and bladder cancer in clinical trials. Gallium can function as an iron mimetic and perturb iron-dependent proliferation and other iron-related processes ...

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Pooled Normal Human Plasma | Catalog No.: IPLA-N

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Innovative Research's Pooled Normal Human Plasma is collected from single donors between the ages of 18 and 65 and pooled per FDA regulations. The material undergoes viral testing, and the final product is aliquoted to customer specifications. Each unit is tested and found negative for HBsAg, HCV, HIV-1, HIV-2, HIV-1Ag or HIV 1-NAT, ALT, and syphilis by FDA-Approved Methods.

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An alkylating agent adds an alkyl group (C n H 2n+1) to DNA.It attaches the alkyl group to the guanine base of DNA, at the number 7 nitrogen atom of the imidazole ring.. Otherwise known as L-phenylalanine mustard, or L-PAM, melphalan is a phenylalanine derivative of chlormethine.

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Both types of investigations include some search for and the use of biomarkers of response to specific toxins, and their general experimental strategy can be represented by the scheme shown in Figure 2. Two major classes of biological systems are then used in …

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